Lophophora williamsii is a small cactus that comes from Mexico, does not have thorns, and also contains psychoactive substances. The name "peyote" comes from the Spanish "peyōtl" and means "caterpillar cocoon". The first mention of the plant dates back to 1845, when the famous French botanist Charles Antoine Lemaire described it in his book, and later in 1894, Peyote was assigned to the genus Lophophora by the American botanist and educator John Merle Coulter.
Lophophora williamsii can be identified by its clustered green, yellow, or red shoots that grow up to 7 cm (2.76 in) tall.
Flowers open during the day and have a pink, white, red, or yellowish color. Behind the flowers are fruits of an elongated shape, which are pink in color when young, and brownish-white when mature. The seeds contained in the fruits are black and pear-shaped.