Opuntia humifusa is endemic to Northeastern USA and over the border into Ontario, Canada. It grows on sandy soils, rocky outcrops or on cliffs and bluffs, tolerating extensive winter wet, long periods of sub-zero temperatures, heavy frost and deep snowfall. Of all the many Opuntia species that are fully hardy in the UK, Opuntia humifusa is probaby the most suitable for British conditions, tolerating wetter conditions than most Opuntias. Typically in a cold winter, it shrivels somewhat, its skin crinkling and turning purple but when the warm weather of Spring rolls around again, it regains condition and growth is rapid, sprouting many new cladodes.
It's invasive in Ontario and can be invasive in Indiana.