The date palm fruit (Phoenix dactylifera L. Arecaceae) is used in most of the countries of the world and is an essential part of the diet, especially in many Arabian countries. Phoenix dactylifera L. fruits are a rich source of sugars (glucose and fructose), vitamins (A, C, and B complex), fibers, minerals, and phenolic compounds having antioxidant and anti-inflammatory properties. This study is designed to explore the Phoenix dactylifera L. fruit for skin care. A single-blinded, placebo control trial was conducted, including 11 healthy female volunteers after their informed consent. The efficacy of the Phoenix dactylifera L. extract (4%) was evaluated in cream form after one, two, three, four, six, and eight weeks of treatment compared with the baseline. Prior to the study, the composition of the extract was analyzed to understand the underlying mechanisms by which the extract affects skin.