Toxicity. Aristolochia macrophylla contains the natural substance aristolochic acid, which is found in all plants of the family Aristolochiaceae. Aristolochic acid is a very dangerous compound in that this acid is a potent mutagen and carcinogen that can cause urological cancers as well as permanent kidney failure.
Aristolochia macrophylla is a deciduous, woody, climbing vine that is an eastern American native which typically occurs in the wild in rich, moist woods and along streams. Can rapidly grow to 20-30'.