This Begonia plant is as easy to prune as other houseplants. The best time for pruning and cutting its old foliage is at the beginning of the growing season. During these days of active growth, new leaves and stems will immediately take the place of the pruned ones. You should always prune the bottom leaves first that are near to the base. Also, disinfect your gardening shears before using them on your plant. You can use 70% isopropyl alcohol or ethanol to sterilize your blades.