P. tetragona has leathery leaves that grow in pairs of three on fleshy vines. The deep green leaves each have four prominent veins. Like all Peperomia, the P. tetragona inflorescence consists of a 'rat tail' like spike which contains the thousands of unnoticeable tiny flowers. Peperomia plants aren't known for their flowers, as they are fairly unimpressive, resembling a bushy spike or tail.