This species is endemic to Central Mexico, where it occurs in the state of Querétaro de Arteagaand into Hidalgo along the border of the Querétaro river. Extent of occurrence ca 2,500 km2.Altitude: 1.200-2.400 metres over sea level. Mammillaria parkinsonii grows on lime rich soils and calcareous substrate in semi-desert areas characterized by warm-temperate and dry climate. It is severely fragmentation in small sub-populations and occurs in xerophyllous scrub and submontane matorral. Illegal collection and land use change are threats across the range of the species. This cactus is used as an ornamental, and is normally found elsewhere as propagated plants.